BioMaTE – A novel biomanufacturing system to produce bioactive scaffolds for tissue engineering (PTDC/EMS-SIS/7032/2014)
The BioMaTE project aims to develop a disruptive biofabrication system for the production of new biological substitutes-3D scaffolds, using a new strategy for the treatment of osteoporosis, a disease with a major impact on society. This new biomanufacturing system will be optimized to possess high reproducibility which allows better definition of the pores in the scaffold, in order to control both the mechanical strength and molecular diffusion. Due to its innovative internal architecture (100% interconnected), to the external geometry and flexible materials, the structures intended to be produced in this project will have the ability to promote a homogeneous cell colonization (by adjacent tissue cell recruitment), neovascularization, controlled drug release in predefined areas and tissue growth. Appropriate models will be developed both in vitro as in vivo, to determine the biomechanical performance of the structures, the release profile of the drug from the biocomposites scaffolds, and thereafter the level of bone remodelling.
PI: Prof. Dr. Nuno Manuel Fernandes Alves
Partners: ICETA – Instituto de Ciências, Tecnologias e Agroambiente da Universidade do Porto
Funding Agency: Fundação para a Ciência e Tecnologia
Project Reference: PTDC/EMS-SIS/7032/2014| POCI-01-0145-FEDER-016800
Funding: 166.048,00 €